InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NTRK2

Summary

InnateDB Gene

IDBG-636149.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NTRK2

Gene Name

BDNF/NT-3 growth factors receptor precursor

Synonyms

Trk-B; TrkB

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010647

Encoded Proteins

IDBP-688120

BDNF/NT-3 growth factors receptor

IDBP-688122

BDNF/NT-3 growth factors receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148053:
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:79336288-79743284

Strand

Forward strand

Band

Transcripts

ENSBTAT00000061120	ENSBTAP00000053704
ENSBTAT00000014097	ENSBTAP00000014097

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005030	neurotrophin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0048403	brain-derived neurotrophic factor binding
GO:0060175	brain-derived neurotrophic factor-activated receptor activity

Biological Process

GO:0001570	vasculogenesis
GO:0001764	neuron migration
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007528	neuromuscular junction development
GO:0007612	learning
GO:0007623	circadian rhythm
GO:0007631	feeding behavior
GO:0010628	positive regulation of gene expression
GO:0010976	positive regulation of neuron projection development
GO:0014047	glutamate secretion
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019222	regulation of metabolic process
GO:0021954	central nervous system neuron development
GO:0021987	cerebral cortex development
GO:0030182	neuron differentiation
GO:0031547	brain-derived neurotrophic factor receptor signaling pathway
GO:0032314	regulation of Rac GTPase activity
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0038179	neurotrophin signaling pathway
GO:0042490	mechanoreceptor differentiation
GO:0046548	retinal rod cell development
GO:0048709	oligodendrocyte differentiation
GO:0048935	peripheral nervous system neuron development
GO:0051896	regulation of protein kinase B signaling
GO:0060291	long-term synaptic potentiation
GO:2000811	negative regulation of anoikis

Cellular Component

GO:0005768	endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043195	terminal bouton
GO:0043235	receptor complex
GO:0045211	postsynaptic membrane
GO:0097481	neuronal postsynaptic density

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000148053

View Gene Order

ENSMUSG00000055254

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_11046

NGF-independant TRKA activation pathway

REACT_11061

Signalling by NGF pathway

REACT_111102

Signal Transduction pathway

REACT_12056

NGF signalling via TRKA from the plasma membrane pathway

REACT_11064

Activation of TRKA receptors pathway

REACT_248921

Signalling by NGF pathway

REACT_237883

NGF signalling via TRKA from the plasma membrane pathway

REACT_188257

Signal Transduction pathway

REACT_209347

NGF-independant TRKA activation pathway

REACT_217410

Activation of TRKA receptors pathway

KEGG

hsa04010

MAPK signaling pathway pathway

hsa04722

Neurotrophin signaling pathway pathway

mmu04010

MAPK signaling pathway pathway

mmu04722

Neurotrophin signaling pathway pathway

INOH

PID NCI

trkrpathway

Neurotrophic factor-mediated Trk receptor signaling

ajdiss_2pathway

Posttranslational regulation of adherens junction stability and dissassembly

Cross-References

SwissProt

TrEMBL

Q0VCN4

UniProt Splice Variant

Entrez Gene

505824

UniGene

Bt.106683

RefSeq

NM_001075225 XM_005210377 XM_005210371 XM_005210372 XM_005210373

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC120085 DAAA02023921 DAAA02023922 DAAA02023923 DAAA02023924 DAAA02023925 DAAA02023926 DAAA02023927 DAAA02023928 DAAA02023929 DAAA02023930 DAAA02023931

GenPept

AAI20086

RNA Seq Atlas

505824