InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CAD

Summary

InnateDB Gene

IDBG-636752.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAD

Gene Name

CAD protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017894

Encoded Proteins

IDBP-688811

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000084774:
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:72383287-72404747

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023783

ENSBTAP00000023783

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004070	aspartate carbamoyltransferase activity
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0008716	D-alanine-D-alanine ligase activity
GO:0016597	amino acid binding
GO:0016743	carboxyl- or carbamoyltransferase activity
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0019899	enzyme binding
GO:0046872	metal ion binding

Biological Process

GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
GO:0006520	cellular amino acid metabolic process
GO:0006543	glutamine catabolic process
GO:0006807	nitrogen compound metabolic process
GO:0008152	metabolic process
GO:0070409	carbamoyl phosphate biosynthetic process