Bos taurus Gene: WAS | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-636860.3 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | WAS | ||||||||||||||||
Gene Name | Uncharacterized protein | ||||||||||||||||
Synonyms | |||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000046555 | ||||||||||||||||
Encoded Proteins |
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||
Summary |
[Homo sapiens] WAS interacts with BTK to induce the LPS signalling cascade in macrophages. (Demonstrated in mice)
[Mus musculus] Was interacts with Btk to induce the LPS signalling cascade in macrophages.
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Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000015285:
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known. [provided by RefSeq, Jul 2008] The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5\' UTR sequence, has been described, however, its full-length nature is not known. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome X:91842944-91855473 | ||||||||||||||||
Strand | Forward strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH |
KitReceptor pathway
TCR pathway
BCR pathway
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REACTOME |
Regulation of actin dynamics for phagocytic cup formation pathway
Generation of second messenger molecules pathway
TCR signaling pathway
Innate Immune System pathway
Adaptive Immune System pathway
Immune System pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Innate Immune System pathway
Regulation of actin dynamics for phagocytic cup formation pathway
Immune System pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Adaptive Immune System pathway
Generation of second messenger molecules pathway
TCR signaling pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Pathogenic Escherichia coli infection pathway
Adherens junction pathway
Fc gamma R-mediated phagocytosis pathway
Chemokine signaling pathway pathway
Bacterial invasion of epithelial cells pathway
Shigellosis pathway
Regulation of actin cytoskeleton pathway
Adherens junction pathway
Fc gamma R-mediated phagocytosis pathway
Chemokine signaling pathway pathway
Bacterial invasion of epithelial cells pathway
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INOH | |||||||||||||||||
PID NCI |
TCR signaling in naïve CD4+ T cells
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Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | G3N3E1 | ||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | |||||||||||||||||
UniGene | |||||||||||||||||
RefSeq | |||||||||||||||||
HUGO | HGNC:12731 | ||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | DAAA02073063 DAAA02073064 DAAA02073065 DAAA02073066 | ||||||||||||||||
GenPept | |||||||||||||||||
RNA Seq Atlas | |||||||||||||||||