InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PAH

Summary

InnateDB Gene

IDBG-637169.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAH

Gene Name

Phenylalanine-4-hydroxylase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012794

Encoded Proteins

IDBP-689157

Phenylalanine-4-hydroxylase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171759:
PAH encodes the enzyme phenylalanine hydroxylase that is the rate-limiting step in phenylalanine catabolism. Deficiency of this enzyme activity results in the autosomal recessive disorder phenylketonuria. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:66950501-67040705

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000016999

ENSBTAP00000016999

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004497	monooxygenase activity
GO:0004505	phenylalanine 4-monooxygenase activity
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0016597	amino acid binding
GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0046872	metal ion binding

Biological Process

GO:0006559	L-phenylalanine catabolic process
GO:0008152	metabolic process
GO:0009072	aromatic amino acid family metabolic process
GO:0055114	oxidation-reduction process