InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ACTN4

Summary

InnateDB Gene

IDBG-637203.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTN4

Gene Name

Alpha-actinin-4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011215

Encoded Proteins

IDBP-689208

Alpha-actinin-4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130402:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:48668482-48741185

Strand

Forward strand

Band

Transcripts

ENSBTAT00000014894

ENSBTAP00000014894

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001882	nucleoside binding
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0051015	actin filament binding

Biological Process

GO:0006810	transport
GO:0015031	protein transport
GO:0048549	positive regulation of pinocytosis
GO:0051017	actin filament bundle assembly
GO:0051271	negative regulation of cellular component movement
GO:0051272	positive regulation of cellular component movement
GO:0070830	tight junction assembly
GO:1902396	protein localization to tight junction

Cellular Component

GO:0001725	stress fiber
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005911	cell-cell junction
GO:0030018	Z disc
GO:0030054	cell junction
GO:0030529	ribonucleoprotein complex
GO:0030863	cortical cytoskeleton
GO:0031143	pseudopodium
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome