InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHST14

Summary

InnateDB Gene

IDBG-6373.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHST14

Gene Name

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000169105

Encoded Proteins

IDBP-6375

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14

IDBP-596018

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:40470998-40474571

Strand

Forward strand

Band

q15.1

Transcripts

ENST00000306243	ENSP00000307297
ENST00000559991	ENSP00000453882

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity
GO:0005515	protein binding
GO:0008146	sulfotransferase activity
GO:0042301	phosphate ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0016051	carbohydrate biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030208	dermatan sulfate biosynthetic process
GO:0044281	small molecule metabolic process
GO:0050655	dermatan sulfate proteoglycan metabolic process