InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ABP1

Summary

InnateDB Gene

IDBG-637428.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABP1

Gene Name

amiloride-sensitive amine oxidase precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005419

Encoded Proteins

IDBP-689440

amiloride-sensitive amine oxidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000002726:
This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:114249782-114262317

Strand

Forward strand

Band

Transcripts

ENSBTAT00000007133

ENSBTAP00000007133

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005261	cation channel activity
GO:0005507	copper ion binding
GO:0005509	calcium ion binding
GO:0008131	primary amine oxidase activity
GO:0008144	drug binding
GO:0008201	heparin binding
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0032403	protein complex binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0048038	quinone binding
GO:0052597	diamine oxidase activity

Biological Process

GO:0006812	cation transport
GO:0009308	amine metabolic process
GO:0035874	cellular response to copper ion starvation
GO:0042493	response to drug
GO:0046677	response to antibiotic
GO:0055114	oxidation-reduction process
GO:0071280	cellular response to copper ion
GO:0071420	cellular response to histamine
GO:0097185	cellular response to azide