InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ANKRD1

Summary

InnateDB Gene

IDBG-637468.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANKRD1

Gene Name

Ankyrin repeat domain-containing protein 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011734

Encoded Proteins

IDBP-689482

Ankyrin repeat domain-containing protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148677:
The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 26:12571209-12580580

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000015584

ENSBTAP00000015584

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0031432	titin binding
GO:0042826	histone deacetylase binding
GO:0070412	R-SMAD binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0035690	cellular response to drug
GO:0035914	skeletal muscle cell differentiation
GO:0035994	response to muscle stretch
GO:0043065	positive regulation of apoptotic process
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050714	positive regulation of protein secretion
GO:0055008	cardiac muscle tissue morphogenesis
GO:0071222	cellular response to lipopolysaccharide
GO:0071260	cellular response to mechanical stimulus
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:2000279	negative regulation of DNA biosynthetic process