InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.32772

Summary

InnateDB Gene

IDBG-637513.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.32772

Gene Name

ATP-binding cassette sub-family B member 8, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007759

Encoded Proteins

IDBP-689529

ATP-binding cassette sub-family B member 8, mitochondrial

IDBP-689532

ATP-binding cassette sub-family B member 8, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197150:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes. [provided by RefSeq, Jul 2008]
This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:114404772-114422140

Strand

Forward strand

Band

Transcripts

ENSBTAT00000064324	ENSBTAP00000054696
ENSBTAT00000043827	ENSBTAP00000041369

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0008152	metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000197150

View Gene Order

ENSMUSG00000028973

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_111108

Mitochondrial ABC transporters pathway

REACT_15480

ABC-family proteins mediated transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

KEGG

hsa02010

ABC transporters pathway

mmu02010

ABC transporters pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F1MQ79 G3MYQ9

UniProt Splice Variant

Entrez Gene

511548

UniGene

Bt.100871 Bt.32772

RefSeq

NM_001075526

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02012012

GenPept

RNA Seq Atlas

511548