Version 5.4
Homo sapiens Gene: GPER
Summary
InnateDB Gene IDBG-6376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPER
Gene Name G protein-coupled estrogen receptor 1
Synonyms CEPR; CMKRL2; DRY12; FEG-1; GPCR-Br; GPER; GPR30; LERGU; LERGU2; LyGPR; mER
Species Homo sapiens
Ensembl Gene ENSG00000164850
Encoded Proteins
IDBP-6378
G protein-coupled estrogen receptor 1
IDBP-236132
G protein-coupled estrogen receptor 1
IDBP-236134
G protein-coupled estrogen receptor 1
IDBP-292471
G protein-coupled estrogen receptor 1
IDBP-361117
G protein-coupled estrogen receptor 1
IDBP-807142
G protein-coupled estrogen receptor 1
IDBP-807143
G protein-coupled estrogen receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:1082208-1093815
Strand Forward strand
Band p22.3
Transcripts
ENST00000297469 ENSP00000297469
ENST00000397092 ENSP00000380281
ENST00000397088 ENSP00000380277
ENST00000401670 ENSP00000385151
ENST00000413368 ENSP00000410487
ENST00000619052 ENSP00000483756
ENST00000617001 ENSP00000479553
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004930 G-protein coupled receptor activity
GO:0005496 steroid binding
GO:0005515 protein binding
GO:0017082 mineralocorticoid receptor activity
GO:0030284 estrogen receptor activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0001956 positive regulation of neurotransmitter secretion
GO:0002695 negative regulation of leukocyte activation
GO:0006954 inflammatory response
GO:0007049 cell cycle
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0019228 neuronal action potential
GO:0030263 apoptotic chromosome condensation
GO:0030264 nuclear fragmentation involved in apoptotic nuclear change
GO:0030335 positive regulation of cell migration
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0031959 mineralocorticoid receptor signaling pathway
GO:0032024 positive regulation of insulin secretion
GO:0032962 positive regulation of inositol trisphosphate biosynthetic process
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0043410 positive regulation of MAPK cascade
GO:0045087 innate immune response
GO:0045599 negative regulation of fat cell differentiation
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045909 positive regulation of vasodilation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050728 negative regulation of inflammatory response
GO:0050769 positive regulation of neurogenesis
GO:0051053 negative regulation of DNA metabolic process
GO:0051055 negative regulation of lipid biosynthetic process
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051480 cytosolic calcium ion homeostasis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070474 positive regulation of uterine smooth muscle contraction
GO:0071157 negative regulation of cell cycle arrest
GO:0071333 cellular response to glucose stimulus
GO:0071356 cellular response to tumor necrosis factor
GO:0071375 cellular response to peptide hormone stimulus
GO:0071389 cellular response to mineralocorticoid stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0014069 postsynaptic density
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0030659 cytoplasmic vesicle membrane
GO:0031966 mitochondrial membrane
GO:0032591 dendritic spine membrane
GO:0042734 presynaptic membrane
GO:0043198 dendritic shaft
GO:0043679 axon terminus
GO:0044327 dendritic spine head
GO:0045095 keratin filament
GO:0048471 perinuclear region of cytoplasm
GO:0048786 presynaptic active zone
GO:0055037 recycling endosome
GO:0097481 neuronal postsynaptic density
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053647
View Gene Order
ENSBTAG00000048154
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.20961
RefSeq NM_001039966 NM_001098201 NM_001505
HUGO
OMIM
CCDS CCDS5322
HPRD 03484
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca