InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HEPH

Summary

InnateDB Gene

IDBG-637628.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HEPH

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000047416

Encoded Proteins

IDBP-689690

hephaestin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089472:
The protein encoded by this gene is similar to an iron transport protein found in mouse. The mouse protein is similar to ceruloplasmin, a serum multi-copper ferroxidase, and is thought to be a membrane-bound protein responsible for transport of dietary iron from epithelial cells of the intestinal lumen into the circulatory system. In mouse, defects in this gene can lead to severe microcytic anemia. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2008]
This gene encodes a member of the multicopper oxidase protein family. The encoded protein is involved in the transport of dietary iron from epithelial cells of the intestinal lumen into the circulatory system, and may be involved in copper transport and homeostasis. In mouse, defects in this gene can lead to severe microcytic anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:99644622-99768588

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000064640

ENSBTAP00000054213

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004322	ferroxidase activity
GO:0005507	copper ion binding
GO:0008198	ferrous iron binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding