Bos taurus Gene: BT.106570 | |||||||||||||
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Summary | |||||||||||||
InnateDB Gene | IDBG-637852.3 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | BT.106570 | ||||||||||||
Gene Name | GTP-binding protein Rheb precursor | ||||||||||||
Synonyms | |||||||||||||
Species | Bos taurus | ||||||||||||
Ensembl Gene | ENSBTAG00000031861 | ||||||||||||
Encoded Proteins |
GTP-binding protein Rheb precursor
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Protein Structure | |||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||
Summary |
[Mus musculus] Mycobacterial infection induces expression of Mir155, which promotes the maturation of phagosomes and represses the expression of Rheb by targeting its 3â??UTR
[Mus musculus] The interplay between Tsc1-Rheb-mTOR complex 1 signalling and Myc-dependent metabolism are dynamically regulated during dentritic cell (DC) development, whereas uncontrolled mTORC1 activation impairs DC development.
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Entrez Gene | |||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106615:
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||
Type | Protein coding | ||||||||||||
Genomic Location | Chromosome 4:114803157-114855282 | ||||||||||||
Strand | Reverse strand | ||||||||||||
Band | |||||||||||||
Transcripts |
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Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||
NETPATH | |||||||||||||
REACTOME |
Release of eIF4E pathway
S6K1-mediated signalling pathway
Regulation of Rheb GTPase activity by AMPK pathway
mTOR signalling pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
PKB-mediated events pathway
mTORC1-mediated signalling pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Insulin receptor signalling cascade pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Signaling by Insulin receptor pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Release of eIF4E pathway
Insulin receptor signalling cascade pathway
S6K1-mediated signalling pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Regulation of Rheb GTPase activity by AMPK pathway
PI3K Cascade pathway
IRS-related events pathway
IRS-mediated signalling pathway
mTORC1-mediated signalling pathway
Signal Transduction pathway
mTOR signalling pathway
PKB-mediated events pathway
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KEGG |
mTOR signaling pathway pathway
Insulin signaling pathway pathway
Insulin signaling pathway pathway
mTOR signaling pathway pathway
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INOH |
Insulin receptor signaling pathway
Insulin receptor signaling pathway
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PID NCI |
mTOR signaling pathway
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Cross-References | |||||||||||||
SwissProt | |||||||||||||
TrEMBL | F2Z4I1 | ||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 528204 | ||||||||||||
UniGene | Bt.9491 | ||||||||||||
RefSeq | NM_001031764 | ||||||||||||
HUGO | HGNC:10011 | ||||||||||||
OMIM | |||||||||||||
CCDS | |||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | DAAA02012028 DAAA02012029 DAAA02012030 | ||||||||||||
GenPept | |||||||||||||
RNA Seq Atlas | 528204 | ||||||||||||