InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CTH

Summary

InnateDB Gene

IDBG-637937.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTH

Gene Name

cystathionine gamma-lyase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014791

Encoded Proteins

IDBP-689977

cystathionine gamma-lyase

IDBP-689979

cystathionine gamma-lyase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116761:
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:75082359-75109443

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000019679	ENSBTAP00000019679
ENSBTAT00000063885	ENSBTAP00000056275

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004123	cystathionine gamma-lyase activity
GO:0005515	protein binding
GO:0030170	pyridoxal phosphate binding
GO:0044540	L-cystine L-cysteine-lyase (deaminating)

Biological Process

GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0018272	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044524	protein sulfhydration
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051289	protein homotetramerization
GO:0070814	hydrogen sulfide biosynthetic process
GO:2001234	negative regulation of apoptotic signaling pathway