Version 5.4
Bos taurus Gene: DDX3X
Summary
InnateDB Gene IDBG-637947.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX3X
Gene Name ATP-dependent RNA helicase DDX3X
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000035907
Encoded Proteins
IDBP-689987
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18583960
[Homo sapiens] DDX3X is a critical component of the TANK-binding kinase 1 (TBK1)-dependent innate immune response.
PMID 20127681
[Homo sapiens] DDX3X is an antiviral MAVS (IPS-1) enhancer, where it can bind viral RNA to join it in the MAVS complex and this augments virus-mediated IFN-beta induction and host cell protection against virus infection.
PMID 20657822
[Homo sapiens] DDX3X RNA helicase can augment TBK1/IKKepsilon activity and hepatitis B virus (HBV) polymerase (HBV Pol) inhibits this TBK1/IKBKE activity by disrupting the interaction between IKBKE and DDX3X, providing an explanation for how HBV evades innate immune response in the early phase of the infection.
PMID 25740981
[Homo sapiens] DDX3X initiates a multifaceted cellular program involving dynamic associations with hepatitis C virus (HCV) RNA and proteins, CHUK, stress granules, and lipid droplet surfaces for its crucial role in the HCV life cycle.
PMID 26454002
[Homo sapiens] DDX3X participates in antiviral innate immunity by controlling translation of PRKRA.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000215301:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which interacts specifically with hepatitis C virus core protein resulting a change in intracellular location. This gene has a homolog located in the nonrecombining region of the Y chromosome. The protein sequence is 91% identical between this gene and the Y-linked homolog. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a homolog located in the nonrecombining region of the Y chromosome, and multiple pseudogenes to this homolog have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome X:107678777-107691829
Strand Reverse strand
Band
Transcripts
ENSBTAT00000050399 ENSBTAP00000047104
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 111 interaction(s) predicted by orthology.
Predicted by orthology
Total 111 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0008134 transcription factor binding
GO:0008143 poly(A) binding
GO:0008190 eukaryotic initiation factor 4E binding
GO:0016787 hydrolase activity
GO:0016887 ATPase activity
GO:0031369 translation initiation factor binding
GO:0035613 RNA stem-loop binding
GO:0043024 ribosomal small subunit binding
GO:0044822 poly(A) RNA binding
GO:0048027 mRNA 5'-UTR binding
Biological Process
GO:0007059 chromosome segregation
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009615 response to virus
GO:0010501 RNA secondary structure unwinding
GO:0017148 negative regulation of translation
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0031333 negative regulation of protein complex assembly
GO:0032508 DNA duplex unwinding
GO:0034063 stress granule assembly
GO:0035556 intracellular signal transduction
GO:0042256 mature ribosome assembly
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response
GO:0045727 positive regulation of translation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045948 positive regulation of translational initiation
GO:0071243 cellular response to arsenic-containing substance
GO:0071470 cellular response to osmotic stress
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0010494 cytoplasmic stress granule
GO:0022627 cytosolic small ribosomal subunit
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Homo sapiens
Gene ID
Gene Order
ENSMUSG00000000787
View Gene Order
ENSG00000215301
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
REACTOME
KEGG
mmu04622
RIG-I-like receptor signaling pathway pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G5E631
UniProt Splice Variant
Entrez Gene 510093
UniGene Bt.9783
RefSeq NM_001192962 XM_005228285 XM_005228286 XM_005228287
HUGO HGNC:2745
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02073612
GenPept
RNA Seq Atlas 510093

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca