Bos taurus Gene: NCF4 | |||||||||||
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Summary | |||||||||||
InnateDB Gene | IDBG-638107.3 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | NCF4 | ||||||||||
Gene Name | neutrophil cytosol factor 4 | ||||||||||
Synonyms | |||||||||||
Species | Bos taurus | ||||||||||
Ensembl Gene | ENSBTAG00000007531 | ||||||||||
Encoded Proteins |
neutrophil cytosol factor 4
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Protein Structure | |||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
Entrez Gene | |||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100365:
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||
Type | Protein coding | ||||||||||
Genomic Location | Chromosome 5:75641217-75659769 | ||||||||||
Strand | Forward strand | ||||||||||
Band | |||||||||||
Transcripts |
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Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||
NETPATH | |||||||||||
REACTOME |
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
Phagosomal maturation (early endosomal stage) pathway
Signaling by VEGF pathway
Signal Transduction pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
VEGFA-VEGFR2 Pathway pathway
Class I MHC mediated antigen processing & presentation pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
Class I MHC mediated antigen processing & presentation pathway
Disease pathway
Signaling by VEGF pathway
Phagosomal maturation (early endosomal stage) pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Immune System pathway
VEGFA-VEGFR2 Pathway pathway
Antigen processing-Cross presentation pathway
Cross-presentation of particulate exogenous antigens (phagosomes) pathway
Adaptive Immune System pathway
Signal Transduction pathway
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KEGG |
Leukocyte transendothelial migration pathway
Leishmaniasis pathway
Osteoclast differentiation pathway
Phagosome pathway
Leukocyte transendothelial migration pathway
Leishmaniasis pathway
Osteoclast differentiation pathway
Phagosome pathway
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INOH | |||||||||||
PID NCI | |||||||||||
Cross-References | |||||||||||
SwissProt | |||||||||||
TrEMBL | Q2HJA6 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 507859 | ||||||||||
UniGene | Bt.7625 | ||||||||||
RefSeq | NM_001045983 | ||||||||||
HUGO | |||||||||||
OMIM | |||||||||||
CCDS | |||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | BC113230 DAAA02013838 | ||||||||||
GenPept | AAI13231 | ||||||||||
RNA Seq Atlas | 507859 | ||||||||||