InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MFNG

Summary

InnateDB Gene

IDBG-638264.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MFNG

Gene Name

beta-1,3-N-acetylglucosaminyltransferase manic fringe

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015043

Encoded Proteins

IDBP-690331

beta-1,3-N-acetylglucosaminyltransferase manic fringe

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100060:
This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:76266277-76282792

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000020023

ENSBTAP00000020023

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity

Biological Process

GO:0007389	pattern specification process
GO:0008152	metabolic process
GO:0032092	positive regulation of protein binding
GO:0045747	positive regulation of Notch signaling pathway