Version 5.4
Bos taurus Gene: FLCN
Summary
InnateDB Gene IDBG-638335.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FLCN
Gene Name Folliculin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008010
Encoded Proteins
IDBP-690399
Folliculin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154803:
This gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:35520080-35536118
Strand Forward strand
Band
Transcripts
ENSBTAT00000010532 ENSBTAP00000010532
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032403 protein complex binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0001932 regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0007043 cell-cell junction assembly
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010823 negative regulation of mitochondrion organization
GO:0030097 hemopoiesis
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031929 TOR signaling
GO:0032006 regulation of TOR signaling
GO:0032007 negative regulation of TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0032465 regulation of cytokinesis
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035065 regulation of histone acetylation
GO:0043065 positive regulation of apoptotic process
GO:0045785 positive regulation of cell adhesion
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051898 negative regulation of protein kinase B signaling
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:1900181 negative regulation of protein localization to nucleus
GO:1901723 negative regulation of cell proliferation involved in kidney development
GO:1901856 negative regulation of cellular respiration
GO:1901859 negative regulation of mitochondrial DNA metabolic process
GO:1901862 negative regulation of muscle tissue development
GO:1901874 negative regulation of post-translational protein modification
GO:2000506 negative regulation of energy homeostasis
GO:2000973 regulation of pro-B cell differentiation
GO:2001170 negative regulation of ATP biosynthetic process
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0030496 midbody
GO:0044291 cell-cell contact zone
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000154803
View Gene Order
ENSMUSG00000032633
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05211
Renal cell carcinoma pathway
mmu05211
Renal cell carcinoma pathway
INOH
PID NCI
Cross-References
SwissProt Q3B7L5
TrEMBL Q0V8J8
UniProt Splice Variant
Entrez Gene 526652
UniGene Bt.41523
RefSeq NM_001035363 XM_005220372
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC107555 BT026220
GenPept AAI07556 ABG67059
RNA Seq Atlas 526652

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca