Version 5.4
Bos taurus Gene: KCNJ12
Summary
InnateDB Gene IDBG-638403.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNJ12
Gene Name ATP-sensitive inward rectifier potassium channel 12
Synonyms IRK2; KIR2.2
Species Bos taurus
Ensembl Gene ENSBTAG00000020061
Encoded Proteins
IDBP-690469
ATP-sensitive inward rectifier potassium channel 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184185:
This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:35955796-35991013
Strand Forward strand
Band
Transcripts
ENSBTAT00000026726 ENSBTAP00000056563
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005242 inward rectifier potassium channel activity
GO:0005244 voltage-gated ion channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000184185
View Gene Order
ENSMUSG00000042529
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25004
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
REACT_25031
GABA B receptor activation pathway
REACT_75831
Activation of G protein gated Potassium channels pathway
REACT_75870
Classical Kir channels pathway
REACT_13685
Neuronal System pathway
REACT_25199
GABA receptor activation pathway
REACT_75780
G protein gated Potassium channels pathway
REACT_25330
Activation of GABAB receptors pathway
REACT_75918
Inwardly rectifying K+ channels pathway
REACT_75908
Potassium Channels pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_214393
Inwardly rectifying K+ channels pathway
REACT_208267
G protein gated Potassium channels pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_207065
Activation of GABAB receptors pathway
REACT_202800
Potassium Channels pathway
REACT_217868
GABA B receptor activation pathway
REACT_224131
GABA receptor activation pathway
REACT_259290
Neuronal System pathway
REACT_199076
Classical Kir channels pathway
REACT_226457
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_208837
Activation of G protein gated Potassium channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A2VDS5
UniProt Splice Variant
Entrez Gene 538479
UniGene Bt.46903
RefSeq NM_001024690 XM_005220595 XM_005220596
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133380 DAAA02049020 DAAA02049021 DAAA02049022
GenPept AAI33381
RNA Seq Atlas 538479

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca