Version 5.4
Bos taurus Gene: MEGF8
Summary
InnateDB Gene IDBG-638514.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEGF8
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000031001
Encoded Proteins
IDBP-690618
multiple EGF-like-domains 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105429:
The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:51247602-51291960
Strand Reverse strand
Band
Transcripts
ENSBTAT00000043858 ENSBTAP00000041399
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0003143 embryonic heart tube morphogenesis
GO:0007275 multicellular organismal development
GO:0010468 regulation of gene expression
GO:0030326 embryonic limb morphogenesis
GO:0030509 BMP signaling pathway
GO:0035108 limb morphogenesis
GO:0042074 cell migration involved in gastrulation
GO:0048704 embryonic skeletal system morphogenesis
GO:0048842 positive regulation of axon extension involved in axon guidance
GO:0055113 epiboly involved in gastrulation with mouth forming second
GO:0060971 embryonic heart tube left/right pattern formation
GO:0060972 left/right pattern formation
GO:0061371 determination of heart left/right asymmetry
GO:0071907 determination of digestive tract left/right asymmetry
GO:0097094 craniofacial suture morphogenesis
GO:0097155 fasciculation of sensory neuron axon
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000105429
View Gene Order
ENSMUSG00000045039
View Gene Order
Cross-References
SwissProt
TrEMBL E1BPS6
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO HGNC:3233
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02047205 DAAA02047206 DAAA02047207 DAAA02047208 DAAA02047209 DAAA02047210
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca