Version 5.4
Bos taurus Gene: BT.40485
Summary
InnateDB Gene IDBG-638601.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.40485
Gene Name ubiquitin carboxyl-terminal hydrolase 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020451
Encoded Proteins
IDBP-690677
ubiquitin carboxyl-terminal hydrolase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162607:
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:83661017-83672269
Strand Reverse strand
Band
Transcripts
ENSBTAT00000027254 ENSBTAP00000027254
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0001501 skeletal system development
GO:0006282 regulation of DNA repair
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0009411 response to UV
GO:0016579 protein deubiquitination
GO:0035520 monoubiquitinated protein deubiquitination
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000162607
View Gene Order
ENSMUSG00000028560
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18265
Regulation of the Fanconi anemia pathway pathway
REACT_18410
Fanconi Anemia pathway pathway
REACT_216
DNA Repair pathway
REACT_233397
DNA Repair pathway
REACT_232842
Fanconi Anemia pathway pathway
REACT_260435
Regulation of the Fanconi anemia pathway pathway
KEGG
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
Cross-References
SwissProt
TrEMBL F1MKU4
UniProt Splice Variant
Entrez Gene 516328
UniGene Bt.40485
RefSeq NM_001046224
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02008676
GenPept
RNA Seq Atlas 516328

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca