Version 5.4
Bos taurus Gene: NFIA
Summary
InnateDB Gene IDBG-638672.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFIA
Gene Name nuclear factor 1 A-type
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000074
Encoded Proteins
IDBP-690759
nuclear factor 1 A-type
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26259914
[Mus musculus] During sepsis-induced generation of myeloid-derived suppressor cells, transcription factor Nfia represses Cdkn1a to arrest differentiation of Gr1+ CD11b+ cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162599:
This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:84749656-85167847
Strand Reverse strand
Band
Transcripts
ENSBTAT00000033431 ENSBTAP00000033344
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008134 transcription factor binding
Biological Process
GO:0006260 DNA replication
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000162599
View Gene Order
ENSMUSG00000028565
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_63
RNA Polymerase III Transcription Termination pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_261233
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_233572
Gene Expression pathway
REACT_221403
RNA Polymerase III Transcription Termination pathway
REACT_237241
RNA Polymerase III Transcription pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q32LP5
UniProt Splice Variant
Entrez Gene 615371
UniGene Bt.22699
RefSeq NM_001038209 XM_005204523 XM_005204524
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109482 DAAA02008699 DAAA02008700 DAAA02008701 DAAA02008702 DAAA02008703 DAAA02008704
GenPept AAI09483
RNA Seq Atlas 615371

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca