Version 5.4
Bos taurus Gene: FBXW2
Summary
InnateDB Gene IDBG-638799.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXW2
Gene Name F-box/WD repeat-containing protein 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000712
Encoded Proteins
IDBP-690899
F-box/WD repeat-containing protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119402:
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:112057391-112089639
Strand Reverse strand
Band
Transcripts
ENSBTAT00000000956 ENSBTAP00000000956
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000119402
View Gene Order
ENSMUSG00000035949
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16907
Association of TriC/CCT with target proteins during biosynthesis pathway
REACT_16952
Protein folding pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q58D00
TrEMBL
UniProt Splice Variant
Entrez Gene 767863
UniGene Bt.12194 Bt.65902
RefSeq NM_001076974
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120224 BT021554 BT021797
GenPept AAI20225 AAX46401 AAX46644
RNA Seq Atlas 767863

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca