Version 5.4
Bos taurus Gene: HOXB3
Summary
InnateDB Gene IDBG-638920.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXB3
Gene Name homeobox protein Hox-B3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021427
Encoded Proteins
IDBP-691023
homeobox B3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120093:
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38573225-38576915
Strand Reverse strand
Band
Transcripts
ENSBTAT00000028563 ENSBTAP00000028563
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0009952 anterior/posterior pattern specification
GO:0021546 rhombomere development
GO:0021615 glossopharyngeal nerve morphogenesis
GO:0030878 thyroid gland development
GO:0048704 embryonic skeletal system morphogenesis
GO:0050767 regulation of neurogenesis
GO:0051216 cartilage development
GO:0060216 definitive hemopoiesis
GO:0060324 face development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000120093
View Gene Order
ENSMUSG00000048763
View Gene Order
Cross-References
SwissProt
TrEMBL A5PKI4
UniProt Splice Variant
Entrez Gene 618214
UniGene Bt.27955
RefSeq NM_001099174 XM_005220632 XM_005220633 XM_005220634
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142499 DAAA02049067
GenPept AAI42500
RNA Seq Atlas 618214

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca