Version 5.4
Bos taurus Gene: PKP1
Summary
InnateDB Gene IDBG-638933.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKP1
Gene Name Plakophilin-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000046350
Encoded Proteins
IDBP-691040
plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000081277:
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:81683387-81720203
Strand Forward strand
Band
Transcripts
ENSBTAT00000063780 ENSBTAP00000055583
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0005521 lamin binding
Biological Process
GO:0007155 cell adhesion
GO:0016337 single organismal cell-cell adhesion
GO:0045110 intermediate filament bundle assembly
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0030057 desmosome
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000081277
View Gene Order
ENSMUSG00000026413
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13579
Apoptotic cleavage of cell adhesion proteins pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_578
Apoptosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3N156
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO HGNC:9023
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02044020 DAAA02044021 DAAA02044022 DAAA02044023 DAAA02044024 DAAA02044025
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca