InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.62768

Summary

InnateDB Gene

IDBG-638938.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.62768

Gene Name

sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Synonyms

SERCA1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006541

Encoded Proteins

IDBP-691060

sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196296:
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:26188434-26204655

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000008593

ENSBTAP00000008593

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0019829	cation-transporting ATPase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006942	regulation of striated muscle contraction
GO:0008152	metabolic process
GO:0008637	apoptotic mitochondrial changes
GO:0031448	positive regulation of fast-twitch skeletal muscle fiber contraction
GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
GO:0034976	response to endoplasmic reticulum stress
GO:0045988	negative regulation of striated muscle contraction
GO:0051561	positive regulation of mitochondrial calcium ion concentration
GO:0051659	maintenance of mitochondrion location
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport
GO:0090076	relaxation of skeletal muscle