Version 5.4
| Bos taurus Gene: BT.34207 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-639103.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | BT.34207 | ||||||||
| Gene Name | prostaglandin E synthase 2 | ||||||||
| Synonyms | MPGES-2 | ||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000016218 | ||||||||
| Encoded Proteins |
prostaglandin E synthase 2
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation from Orthologs | |||||||||
| Summary |
[Homo sapiens] PTGES2 is responsible for nearly half of the increment in NO production by alveolar macrophages in response to LPS stimulation. The enhancing effect of PTGES2 on NO production is mediated through the ligation of PTGER2 and acting via PKA to induce cAMP production. In addition PTGES2 induces expression of cytokines IL10 and IL6, while inhibiting TNFA. (Demonstrated in rat models)
[Mus musculus] Ptges2 is responsible for nearly half of the increment in NO production by alveolar macrophages in response to LPS stimulation. The enhancing effect of Ptges2 on NO production is mediated through the ligation of Ptger2 and acting via PKA to induce cAMP production. In addition Ptges2 induces expression of cytokines Il10 and Il6, while inhibiting Tnfa. (Demonstrated in rat models)
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| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148334:
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 11:98770575-98775940 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG |
Arachidonic acid metabolism pathway
Arachidonic acid metabolism pathway
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| INOH |
Prostaglandin Leukotriene metabolism pathway
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| PID NCI |
IFN-gamma pathway
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | Bt.34207 | ||||||||
| RefSeq | NM_001166554 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||