Version 5.4
Homo sapiens Gene: SIGLEC11
Summary
InnateDB Gene IDBG-63914.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIGLEC11
Gene Name sialic acid binding Ig-like lectin 11
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000161640
Encoded Proteins
IDBP-383603
sialic acid binding Ig-like lectin 11
IDBP-383609
sialic acid binding Ig-like lectin 11
IDBP-383611
sialic acid binding Ig-like lectin 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21208791
SIGLEC11 is a member of the SIGLEC protein family that recognize sialoside-based patterns and plays a role in the attenuation of innate immunity to avoid autoimmune destruction.
Entrez Gene
Summary This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:49948985-49961172
Strand Reverse strand
Band q13.33
Transcripts
ENST00000447370 ENSP00000412361
ENST00000426971 ENSP00000398891
ENST00000426296 ENSP00000407387
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q96RL6
TrEMBL H7BZU6
UniProt Splice Variant
Entrez Gene 114132
UniGene Hs.661852
RefSeq NM_052884 XM_005258477 NM_001135163
HUGO HGNC:15622
OMIM 607157
CCDS CCDS12790 CCDS46150
HPRD 06196
IMGT
EMBL AC011452 AF337818 AY358135
GenPept AAK72907 AAQ88502
RNA Seq Atlas 114132

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca