InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PTPRO

Summary

InnateDB Gene

IDBG-639230.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRO

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006256

Encoded Proteins

IDBP-691394

protein tyrosine phosphatase, receptor type, O

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151490:
This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:94770904-94881418

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000030462

ENSBTAP00000030443

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0017147	Wnt-protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000902	cell morphogenesis
GO:0002548	monocyte chemotaxis
GO:0003093	regulation of glomerular filtration
GO:0003105	negative regulation of glomerular filtration
GO:0006470	protein dephosphorylation
GO:0007411	axon guidance
GO:0016311	dephosphorylation
GO:0030032	lamellipodium assembly
GO:0032835	glomerulus development
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0036060	slit diaphragm assembly
GO:0072112	glomerular visceral epithelial cell differentiation
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0043197	dendritic spine
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000151490

View Gene Order

ENSMUSG00000030223

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

kitpathway

Signaling events mediated by Stem cell factor receptor (c-Kit)

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.111121 Bt.111124

RefSeq

XM_002687771 XM_005198403 XM_005206999 XM_614266

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas