Version 5.4
Bos taurus Gene: CACNB1
Summary
InnateDB Gene IDBG-639283.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACNB1
Gene Name Voltage-dependent L-type calcium channel subunit beta-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002036
Encoded Proteins
IDBP-691437
Voltage-dependent L-type calcium channel subunit beta-1
IDBP-691440
Voltage-dependent L-type calcium channel subunit beta-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067191:
The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:40298255-40312857
Strand Forward strand
Band
Transcripts
ENSBTAT00000043189 ENSBTAP00000040778
ENSBTAT00000002640 ENSBTAP00000002640
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005244 voltage-gated ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0008331 high voltage-gated calcium channel activity
Biological Process
GO:0006612 protein targeting to membrane
GO:0006810 transport
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0030315 T-tubule
GO:0042383 sarcolemma
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000067191
View Gene Order
ENSMUSG00000020882
View Gene Order
Pathways
NETPATH
REACTOME
REACT_220819
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
REACT_217282
NCAM signaling for neurite out-growth pathway
REACT_202514
NCAM1 interactions pathway
REACT_223058
Transmission across Chemical Synapses pathway
REACT_203140
Axon guidance pathway
REACT_225032
Neuronal System pathway
REACT_220844
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18312
NCAM1 interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_13685
Neuronal System pathway
REACT_18266
Axon guidance pathway
REACT_13606
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_236183
NCAM1 interactions pathway
REACT_261444
Axon guidance pathway
REACT_225645
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
REACT_259290
Neuronal System pathway
REACT_188576
Developmental Biology pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_237796
NCAM signaling for neurite out-growth pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
mmu04010
MAPK signaling pathway pathway
mmu04260
Cardiac muscle contraction pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
INOH
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.37145
RefSeq NM_175819
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca