Version 5.4
Bos taurus Gene: CALM
Summary
InnateDB Gene IDBG-639837.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CALM
Gene Name Calmodulin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014583
Encoded Proteins
IDBP-692034
Calmodulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 18:54169313-54178928
Strand Forward strand
Band
Transcripts
ENSBTAT00000019411 ENSBTAP00000019411
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0031432 titin binding
GO:0031996 thioesterase binding
GO:0031997 N-terminal myristoylation domain binding
GO:0043274 phospholipase binding
GO:0044325 ion channel binding
GO:0046872 metal ion binding
GO:0072542 protein phosphatase activator activity
Biological Process
GO:0002027 regulation of heart rate
GO:0005513 detection of calcium ion
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0021762 substantia nigra development
GO:0030801 positive regulation of cyclic nucleotide metabolic process
GO:0032465 regulation of cytokinesis
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0035307 positive regulation of protein dephosphorylation
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051592 response to calcium ion
GO:0055117 regulation of cardiac muscle contraction
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005876 spindle microtubule
GO:0030017 sarcomere
GO:0034704 calcium channel complex
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_202252
Platelet degranulation pathway
REACT_217956
DAP12 interactions pathway
REACT_212636
Signaling by Wnt pathway
REACT_208875
Activation of Kainate Receptors upon glutamate binding pathway
REACT_208036
Signaling by EGFR pathway
REACT_204121
PLCG1 events in ERBB2 signaling pathway
REACT_214130
Ionotropic activity of Kainate Receptors pathway
REACT_221274
Metabolism of carbohydrates pathway
REACT_212364
Ras activation uopn Ca2+ infux through NMDA receptor pathway
REACT_217977
eNOS activation pathway
REACT_226364
Post NMDA receptor activation events pathway
REACT_213099
Muscle contraction pathway
REACT_205369
Signaling by GPCR pathway
REACT_204365
Signaling by PDGF pathway
REACT_205490
DARPP-32 events pathway
REACT_205562
The phototransduction cascade pathway
REACT_202422
Calmodulin induced events pathway
REACT_213902
DAG and IP3 signaling pathway
REACT_226352
eNOS activation and regulation pathway
REACT_214581
Transcriptional activation of mitochondrial biogenesis pathway
REACT_216844
PLC-gamma1 signalling pathway
REACT_220341
Metabolism of nitric oxide pathway
REACT_202837
Signaling by FGFR pathway
REACT_219973
Myoclonic epilepsy of Lafora pathway
REACT_246299
VEGFA-VEGFR2 Pathway pathway
REACT_217718
Translocation of GLUT4 to the plasma membrane pathway
REACT_212196
Hemostasis pathway
REACT_217010
Smooth Muscle Contraction pathway
REACT_213138
Immune System pathway
REACT_223698
Visual phototransduction pathway
REACT_223058
Transmission across Chemical Synapses pathway
REACT_204754
EGFR interacts with phospholipase C-gamma pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_213597
Activation of CaMK IV pathway
REACT_225102
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_229952
VEGFR2 mediated cell proliferation pathway
REACT_216829
FCERI mediated Ca+2 mobilization pathway
REACT_212308
Response to elevated platelet cytosolic Ca2+ pathway
REACT_209727
Ca2+ pathway pathway
REACT_205435
Signaling by the B Cell Receptor (BCR) pathway
REACT_218958
Signaling by ERBB2 pathway
REACT_212942
Cam-PDE 1 activation pathway
REACT_214353
Signal Transduction pathway
REACT_209867
CREB phosphorylation through the activation of CaMKII pathway
REACT_236208
VEGFR2 mediated vascular permeability pathway
REACT_216035
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_216038
Diseases associated with visual transduction pathway
REACT_221368
Signaling by EGFR in Cancer pathway
REACT_211557
G-protein mediated events pathway
REACT_202705
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_209927
CaMK IV-mediated phosphorylation of CREB pathway
REACT_206800
beta-catenin independent WNT signaling pathway
REACT_218305
CREB phosphorylation through the activation of Ras pathway
REACT_211129
Glycogen storage diseases pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_225885
Glycogen breakdown (glycogenolysis) pathway
REACT_213422
PLC beta mediated events pathway
REACT_224672
Glucose metabolism pathway
REACT_206613
Downstream signaling of activated FGFR pathway
REACT_225032
Neuronal System pathway
REACT_219139
Metabolism pathway
REACT_207066
Signalling by NGF pathway
REACT_226693
Signaling by VEGF pathway
REACT_217517
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
REACT_214469
Adaptive Immune System pathway
REACT_211106
Inositol phosphate metabolism pathway
REACT_202198
Phospholipase C-mediated cascade pathway
REACT_212750
Downstream signal transduction pathway
REACT_221074
Activation of Ca-permeable Kainate Receptor pathway
REACT_219672
Opioid Signalling pathway
REACT_227054
CREB phosphorylation through the activation of CaMKK pathway
REACT_216714
Innate Immune System pathway
REACT_223374
Ca-dependent events pathway
REACT_216082
CaM pathway pathway
REACT_214174
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_205675
Mitochondrial biogenesis pathway
REACT_214988
DAP12 signaling pathway
REACT_207087
Disease pathway
REACT_209198
Inactivation, recovery and regulation of the phototransduction cascade pathway
REACT_203736
Signaling by FGFR in disease pathway
REACT_225357
Fc epsilon receptor (FCERI) signaling pathway
REACT_213260
Membrane Trafficking pathway
REACT_219259
Organelle biogenesis and maintenance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.53264 Bt.70989 Bt.72123
RefSeq NM_001046249
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca