Bos taurus Gene: MUTYH | |||||||||||||
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Summary | |||||||||||||
InnateDB Gene | IDBG-640101.3 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | MUTYH | ||||||||||||
Gene Name | A/G-specific adenine DNA glycosylase | ||||||||||||
Synonyms | |||||||||||||
Species | Bos taurus | ||||||||||||
Ensembl Gene | ENSBTAG00000011242 | ||||||||||||
Encoded Proteins |
mutY homolog (E. coli)
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Protein Structure | |||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
Entrez Gene | |||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132781:
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||
Type | Protein coding | ||||||||||||
Genomic Location | Chromosome 3:101324290-101332855 | ||||||||||||
Strand | Forward strand | ||||||||||||
Band | |||||||||||||
Transcripts |
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Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||
NETPATH | |||||||||||||
REACTOME |
Displacement of DNA glycosylase by APE1 pathway
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
Resolution of AP sites via the single-nucleotide replacement pathway pathway
Removal of DNA patch containing abasic residue pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Recognition and association of DNA glycosylase with site containing an affected purine pathway
Cleavage of the damaged purine pathway
Resolution of Abasic Sites (AP sites) pathway
Base Excision Repair pathway
Base-Excision Repair, AP Site Formation pathway
Depurination pathway
DNA Repair pathway
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
Displacement of DNA glycosylase by APE1 pathway
Resolution of AP sites via the single-nucleotide replacement pathway pathway
Base Excision Repair pathway
Base-Excision Repair, AP Site Formation pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Depurination pathway
DNA Repair pathway
Removal of DNA patch containing abasic residue pathway
Cleavage of the damaged purine pathway
Resolution of Abasic Sites (AP sites) pathway
Recognition and association of DNA glycosylase with site containing an affected purine pathway
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KEGG |
Base excision repair pathway
Base excision repair pathway
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INOH | |||||||||||||
PID NCI | |||||||||||||
Cross-References | |||||||||||||
SwissProt | |||||||||||||
TrEMBL | |||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | |||||||||||||
UniGene | |||||||||||||
RefSeq | NM_001046135 XM_005204720 XM_005204721 | ||||||||||||
HUGO | |||||||||||||
OMIM | |||||||||||||
CCDS | |||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | |||||||||||||
GenPept | |||||||||||||
RNA Seq Atlas | |||||||||||||