InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.89463

Summary

InnateDB Gene

IDBG-640312.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.89463

Gene Name

inhibitor of growth protein 4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017064

Encoded Proteins

IDBP-692562

inhibitor of growth protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20534538

[Homo sapiens] ING4 is a member of the inhibitor of growth (ING) family of chromatin-modifying proteins that functions to negatively regulate the cytokine-mediated inflammatory response. In mice, it facilitates NF-kappaB activation of IkappaB promoters, thereby suppressing nuclear RelA (p65) levels and the activation of select NF-kappaB target cytokines.

PMID 20534538

[Mus musculus] Ing4 is a member of the inhibitor of growth (ING) family of chromatin-modifying proteins that functions to negatively regulate the cytokine-mediated inflammatory response in mice by facilitating NF-kappaB activation of IkappaB promoters; thereby suppressing nuclear Rela (p65) levels and the activation of select NF-kappaB target cytokines.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111653:
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:104145507-104152702

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022686

ENSBTAP00000022686

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0035064	methylated histone binding
GO:0046872	metal ion binding

Biological Process

GO:0006260	DNA replication
GO:0006473	protein acetylation
GO:0006915	apoptotic process
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0016568	chromatin modification
GO:0016573	histone acetylation
GO:0043065	positive regulation of apoptotic process
GO:0043966	histone H3 acetylation
GO:0043981	histone H4-K5 acetylation
GO:0043982	histone H4-K8 acetylation
GO:0043983	histone H4-K12 acetylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045926	negative regulation of growth

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0005634	nucleus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000111653

View Gene Order

ENSMUSG00000030330

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_172610

HATs acetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

REACT_218274

Chromatin organization pathway

REACT_226917

HATs acetylate histones pathway

REACT_202766

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F1MD09

UniProt Splice Variant

Entrez Gene

532483

UniGene

Bt.48844 Bt.89463

RefSeq

NM_001035389 XM_005207152 XM_005207153 XM_005207154 XM_005207155 XM_005207156 XM_005207157 XM_005207158

HUGO

HGNC:19423

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02014462

GenPept

RNA Seq Atlas

532483