InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HOXD11

Summary

InnateDB Gene

IDBG-640376.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOXD11

Gene Name

homeobox protein Hox-D11

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000033330

Encoded Proteins

IDBP-692635

homeobox D11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128713:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008]
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5\' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:20839236-20841537

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000054133

ENSBTAP00000051665

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001501	skeletal system development
GO:0001656	metanephros development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001759	organ induction
GO:0006355	regulation of transcription, DNA-templated
GO:0007338	single fertilization
GO:0007389	pattern specification process
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0009954	proximal/distal pattern formation
GO:0010468	regulation of gene expression
GO:0010720	positive regulation of cell development
GO:0030326	embryonic limb morphogenesis
GO:0032330	regulation of chondrocyte differentiation
GO:0032332	positive regulation of chondrocyte differentiation
GO:0035115	embryonic forelimb morphogenesis
GO:0042733	embryonic digit morphogenesis
GO:0048589	developmental growth
GO:0060272	embryonic skeletal joint morphogenesis
GO:0060351	cartilage development involved in endochondral bone morphogenesis

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000128713

View Gene Order

ENSMUSG00000042499

View Gene Order

Cross-References

SwissProt

TrEMBL

E1B9U3 G9BHT7

UniProt Splice Variant

Entrez Gene

613983

UniGene

Bt.87148

RefSeq

NM_001206324

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02004174 HQ585508

GenPept

AEA11446

RNA Seq Atlas

613983