Version 5.4
Bos taurus Gene: BT.56769
Summary
InnateDB Gene IDBG-640426.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.56769
Gene Name WAS/WASL-interacting protein family member 1
Synonyms PRPL-2; WASPIP
Species Bos taurus
Ensembl Gene ENSBTAG00000001585
Encoded Proteins
IDBP-692686
WAS/WASL-interacting protein family member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115935:
This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:22253662-22294719
Strand Forward strand
Band
Transcripts
ENSBTAT00000002076 ENSBTAP00000002076
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0008154 actin polymerization or depolymerization
GO:0030048 actin filament-based movement
GO:0051707 response to other organism
Cellular Component
GO:0005884 actin filament
GO:0015629 actin cytoskeleton
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000115935
View Gene Order
ENSMUSG00000075284
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
NetPath_24
TSLP pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_230745
Immune System pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
KEGG
INOH
PID NCI
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt
TrEMBL F6QPK8
UniProt Splice Variant
Entrez Gene 540304
UniGene Bt.20638
RefSeq NM_001076923 XM_005202348 XM_005202349 XM_005202350
HUGO HGNC:12736
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02004197
GenPept
RNA Seq Atlas 540304

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca