Bos taurus Gene: HRMT1L2 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-640647.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | HRMT1L2 | ||||||||||||||
Gene Name | protein arginine N-methyltransferase 1 | ||||||||||||||
Synonyms | HRMT1L2 | ||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Gene | ENSBTAG00000006646 | ||||||||||||||
Encoded Proteins |
protein arginine N-methyltransferase 1
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||
Summary |
[Homo sapiens] PRMT1 is a protein arginine methyltransferase and a novel and crucial negative regulator of STAT1 activation that controls PIAS1-mediated repression by arginine methylation.
[Homo sapiens] Reversible arginine methylation of TRAF6 is regulated by PRMT1 and JMJD6 and this in turn regulates TRAF6-dependent TLR signalling.
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Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126457:
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 18:56534833-56545053 | ||||||||||||||
Strand | Forward strand | ||||||||||||||
Band | |||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 97 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH |
AndrogenReceptor pathway
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REACTOME |
Chromatin organization pathway
RMTs methylate histone arginines pathway
Chromatin modifying enzymes pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
RMTs methylate histone arginines pathway
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KEGG | |||||||||||||||
INOH | |||||||||||||||
PID NCI |
Direct p53 effectors
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Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | Q5E949 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 520388 | ||||||||||||||
UniGene | Bt.52357 | ||||||||||||||
RefSeq | NM_001015624 XM_005219283 XM_005219284 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | BC109796 BT021071 DAAA02047482 DAAA02047483 | ||||||||||||||
GenPept | AAI09797 AAX09088 | ||||||||||||||
RNA Seq Atlas | 520388 | ||||||||||||||