Version 5.4
Bos taurus Gene: BT.49448
Summary
InnateDB Gene IDBG-640844.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.49448
Gene Name ornithine aminotransferase, mitochondrial precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006928
Encoded Proteins
IDBP-693145
ornithine aminotransferase, mitochondrial precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065154:
This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 26:44378157-44397476
Strand Reverse strand
Band
Transcripts
ENSBTAT00000009097 ENSBTAP00000009097
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004587 ornithine-oxo-acid transaminase activity
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0008152 metabolic process
GO:0034214 protein hexamerization
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000065154
View Gene Order
ENSMUSG00000030934
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_238
Amino acid synthesis and interconversion (transamination) pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_239550
Amino acid synthesis and interconversion (transamination) pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
mmu00330
Arginine and proline metabolism pathway
INOH
INOH website
Arginine Proline metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL F1MYG0
UniProt Splice Variant
Entrez Gene 505323
UniGene Bt.49448
RefSeq NM_001034240
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02059496
GenPept
RNA Seq Atlas 505323

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca