Version 5.4
Bos taurus Gene: OSBPL2
Summary
InnateDB Gene IDBG-640959.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSBPL2
Gene Name oxysterol-binding protein-related protein 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017402
Encoded Proteins
IDBP-693290
oxysterol-binding protein-related protein 2
IDBP-693292
oxysterol-binding protein-related protein 2
IDBP-693297
oxysterol-binding protein-related protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130703:
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:55448212-55464735
Strand Reverse strand
Band
Transcripts
ENSBTAT00000044841 ENSBTAP00000042296
ENSBTAT00000023135 ENSBTAP00000023135
ENSBTAT00000044837 ENSBTAP00000042292
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015485 cholesterol binding
Biological Process
GO:0006810 transport
GO:0006869 lipid transport
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000130703
View Gene Order
ENSMUSG00000039050
View Gene Order
Cross-References
SwissProt
TrEMBL E1BL67
UniProt Splice Variant
Entrez Gene 505328
UniGene Bt.20496
RefSeq XM_005214549 XM_005214550 NM_001035020
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02036259
GenPept
RNA Seq Atlas 505328

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca