Version 5.4
Bos taurus Gene: ARF1
Summary
InnateDB Gene IDBG-641226.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARF1
Gene Name ADP-ribosylation factor 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007725
Encoded Proteins
IDBP-693565
ADP-ribosylation factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143761:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:2913860-2931918
Strand Reverse strand
Band
Transcripts
ENSBTAT00000010159 ENSBTAP00000010159
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0002090 regulation of receptor internalization
GO:0006810 transport
GO:0006878 cellular copper ion homeostasis
GO:0006886 intracellular protein transport
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation
GO:0060292 long term synaptic depression
GO:0097061 dendritic spine organization
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030017 sarcomere
GO:0030054 cell junction
GO:0043005 neuron projection
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000143761
View Gene Order
ENSMUSG00000048076
View Gene Order
Pathways
NETPATH
REACTOME
REACT_211733
Golgi to ER Retrograde Transport pathway
REACT_206224
COPI Mediated Transport pathway
REACT_219531
Golgi Associated Vesicle Biogenesis pathway
REACT_225051
Synthesis of PIPs at the Golgi membrane pathway
REACT_213138
Immune System pathway
REACT_216751
Clathrin derived vesicle budding pathway
REACT_211133
MHC class II antigen presentation pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_211153
trans-Golgi Network Vesicle Budding pathway
REACT_219139
Metabolism pathway
REACT_214469
Adaptive Immune System pathway
REACT_218329
Phospholipid metabolism pathway
REACT_205891
Lysosome Vesicle Biogenesis pathway
REACT_227900
PI Metabolism pathway
REACT_213260
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_23
TSH pathway
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_120836
Synthesis of PIPs at the Golgi membrane pathway
REACT_11166
Nef Mediated CD4 Down-regulation pathway
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11096
COPI Mediated Transport pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_11208
Golgi to ER Retrograde Transport pathway
REACT_6185
HIV Infection pathway
REACT_111217
Metabolism pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
REACT_198970
Synthesis of PIPs at the Golgi membrane pathway
REACT_209837
Membrane Trafficking pathway
REACT_199016
PI Metabolism pathway
REACT_188937
Metabolism pathway
REACT_231722
Lysosome Vesicle Biogenesis pathway
REACT_230745
Immune System pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_232671
Golgi Associated Vesicle Biogenesis pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_234979
Clathrin derived vesicle budding pathway
REACT_229531
Adaptive Immune System pathway
REACT_188643
Phospholipid metabolism pathway
REACT_207127
Golgi to ER Retrograde Transport pathway
REACT_227904
COPI Mediated Transport pathway
KEGG
hsa05110
Vibrio cholerae infection pathway
hsa04144
Endocytosis pathway
mmu04144
Endocytosis pathway
INOH
PID NCI
pi3kcipathway
Class I PI3K signaling events
arf_3pathway
Arf1 pathway
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
arf6downstreampathway
Arf6 downstream pathway
Cross-References
SwissProt P84080
TrEMBL
UniProt Splice Variant
Entrez Gene 510994
UniGene Bt.91076 Bt.927
RefSeq NM_176653 XM_005208399 XM_005208400
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102874 BC140532 J03275
GenPept AAA30361 AAI02875 AAI40533
RNA Seq Atlas 338058 510994

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca