Version 5.4
Bos taurus Gene: MAD1L1
Summary
InnateDB Gene IDBG-641345.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAD1L1
Gene Name mitotic spindle assembly checkpoint protein MAD1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002474
Encoded Proteins
IDBP-693710
mitotic spindle assembly checkpoint protein MAD1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000002822:
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 25:41535263-41778055
Strand Forward strand
Band
Transcripts
ENSBTAT00000003210 ENSBTAP00000003210
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007094 mitotic spindle assembly checkpoint
GO:0007165 signal transduction
GO:0090235 regulation of metaphase plate congression
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
GO:0072686 mitotic spindle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000002822
View Gene Order
ENSMUSG00000029554
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_491
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal pathway
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_115566
Cell Cycle pathway
REACT_2137
Mitotic Spindle Checkpoint pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_795
Amplification of signal from the kinetochores pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_232480
Amplification of signal from the kinetochores pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_234036
Mitotic Spindle Checkpoint pathway
REACT_256672
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal pathway
REACT_202512
Mitotic Anaphase pathway
KEGG
hsa04110
Cell cycle pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
mmu04110
Cell cycle pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.43533
RefSeq NM_001102044
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca