InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: STRADA

Summary

InnateDB Gene

IDBG-641634.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STRADA

Gene Name

STE20-related kinase adapter protein alpha

Synonyms

LYK5

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000056

Encoded Proteins

IDBP-694023

STE20-related kinase adapter protein alpha

IDBP-694024

STE20-related kinase adapter protein alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000266173:
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:48628883-48656396

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000061	ENSBTAP00000000061
ENSBTAT00000053961	ENSBTAP00000051279

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019900	kinase binding
GO:0030295	protein kinase activator activity