Version 5.4
Bos taurus Gene: IFI30
Summary
InnateDB Gene IDBG-641754.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFI30
Gene Name gamma-interferon-inducible lysosomal thiol reductase precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018349
Encoded Proteins
IDBP-694150
gamma-interferon-inducible lysosomal thiol reductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000216490:
The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:4981195-4984553
Strand Reverse strand
Band
Transcripts
ENSBTAT00000047907 ENSBTAP00000045061
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors
Biological Process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0048147 negative regulation of fibroblast proliferation
GO:0050821 protein stabilization
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0030054 cell junction
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Homo sapiens
Gene ID
Gene Order
ENSMUSG00000031838
View Gene Order
ENSG00000216490
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_198660
Interferon gamma signaling pathway
REACT_198666
Interferon Signaling pathway
REACT_229531
Adaptive Immune System pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_25078
Interferon gamma signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
mmu04612
Antigen processing and presentation pathway
hsa04612
Antigen processing and presentation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MAU3
UniProt Splice Variant
Entrez Gene 615930
UniGene Bt.1548
RefSeq NM_001101251
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02019062 DAAA02019063
GenPept
RNA Seq Atlas 615930

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca