Version 5.4
Bos taurus Gene: TNNT1
Summary
InnateDB Gene IDBG-641928.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNNT1
Gene Name Troponin T, slow skeletal muscle
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006419
Encoded Proteins
IDBP-694350
Troponin T, slow skeletal muscle
IDBP-694351
Troponin T, slow skeletal muscle
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105048:
This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:62725898-62735263
Strand Forward strand
Band
Transcripts
ENSBTAT00000008420 ENSBTAP00000008420
ENSBTAT00000064903 ENSBTAP00000054828
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005523 tropomyosin binding
Biological Process
GO:0003009 skeletal muscle contraction
GO:0006937 regulation of muscle contraction
GO:0045932 negative regulation of muscle contraction
Cellular Component
GO:0005861 troponin complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000105048
View Gene Order
ENSMUSG00000064179
View Gene Order
Pathways
NETPATH
REACTOME
REACT_213099
Muscle contraction pathway
REACT_223821
Striated Muscle Contraction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
REACT_232053
Striated Muscle Contraction pathway
REACT_262759
Muscle contraction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8MKH6
TrEMBL B1GVY6 B1GVZ4
UniProt Splice Variant
Entrez Gene 282095
UniGene
RefSeq NM_174474 XM_005219667 XM_005219668 XM_005219669 XM_005219670 XM_005219671 XM_005219672
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB085600 AB085601 AM930546 AM930555 BC118248
GenPept AAI18249 BAB92983 BAB92984 CAP59627 CAP59635
RNA Seq Atlas 282095

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca