Version 5.4
Bos taurus Gene: MBD5
Summary
InnateDB Gene IDBG-642095.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MBD5
Gene Name methyl-CpG-binding domain protein 5
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019592
Encoded Proteins
IDBP-694512
methyl-CpG binding domain protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204406:
This gene encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause mental retardation autosomal dominant type 1. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:47800355-47858327
Strand Reverse strand
Band
Transcripts
ENSBTAT00000061479 ENSBTAP00000053347
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
Biological Process
GO:0007399 nervous system development
GO:0040014 regulation of multicellular organism growth
GO:0042593 glucose homeostasis
GO:0044708 single-organism behavior
GO:0060399 positive regulation of growth hormone receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0010369 chromocenter
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000204406
View Gene Order
ENSMUSG00000036792
View Gene Order
Cross-References
SwissProt
TrEMBL E1BPU6
UniProt Splice Variant
Entrez Gene 541084
UniGene Bt.44103
RefSeq NM_001191268 XM_005202494
HUGO HGNC:20444
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02004663
GenPept
RNA Seq Atlas 541084

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca