Version 5.4
Bos taurus Gene: PRMT3
Summary
InnateDB Gene IDBG-642283.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRMT3
Gene Name protein arginine N-methyltransferase 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013421
Encoded Proteins
IDBP-694745
protein arginine N-methyltransferase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185238:
Type I protein arginine N-methyltransferases (PRMTs), such as PRMT3, catalyze the formation of asymmetric N(G),N(G)-dimethylarginine (ADMA) residues in proteins (Tang et al., 1998 [PubMed 9642256]).[supplied by OMIM, Mar 2008]
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:24684060-24806790
Strand Reverse strand
Band
Transcripts
ENSBTAT00000017861 ENSBTAP00000017861
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0008469 histone-arginine N-methyltransferase activity
GO:0016740 transferase activity
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006479 protein methylation
GO:0008152 metabolic process
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0031397 negative regulation of protein ubiquitination
GO:0032259 methylation
GO:0034969 histone arginine methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000185238
View Gene Order
ENSMUSG00000030505
View Gene Order
Cross-References
SwissProt
TrEMBL A6QL80
UniProt Splice Variant
Entrez Gene 523174
UniGene Bt.39827
RefSeq NM_001102076
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC147870 DAAA02062944 DAAA02062945 DAAA02062946
GenPept AAI47871
RNA Seq Atlas 523174

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca