Bos taurus Gene: MARCO | |||||||
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Summary | |||||||
InnateDB Gene | IDBG-642407.3 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | MARCO | ||||||
Gene Name | Uncharacterized protein | ||||||
Synonyms | |||||||
Species | Bos taurus | ||||||
Ensembl Gene | ENSBTAG00000018473 | ||||||
Encoded Proteins |
macrophage receptor with collagenous structure
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Protein Structure | |||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||
InnateDB Annotation from Orthologs | |||||||
Summary |
[Homo sapiens] MARCO is upregulated in TLR4-mediated LPS responses and these receptors contribute to the efficient capturing and clearance of invading microbial pathogens.
[Mus musculus] Autophagy regulates phagocytosis by modulating the expression of scavenger receptors, Marco and Msr1
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Entrez Gene | |||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000019169:
The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||
Type | Protein coding | ||||||
Genomic Location | Chromosome 2:71099131-71134074 | ||||||
Strand | Forward strand | ||||||
Band | |||||||
Transcripts |
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Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||
NETPATH | |||||||
REACTOME |
Binding and Uptake of Ligands by Scavenger Receptors pathway
Scavenging by Class A Receptors pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Scavenging by Class A Receptors pathway
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KEGG |
Phagosome pathway
Phagosome pathway
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INOH | |||||||
PID NCI | |||||||
Cross-References | |||||||
SwissProt | |||||||
TrEMBL | F1N7K7 | ||||||
UniProt Splice Variant | |||||||
Entrez Gene | |||||||
UniGene | |||||||
RefSeq | |||||||
HUGO | HGNC:6895 | ||||||
OMIM | |||||||
CCDS | |||||||
HPRD | |||||||
IMGT | |||||||
EMBL | DAAA02005179 DAAA02005180 DAAA02005181 | ||||||
GenPept | |||||||
RNA Seq Atlas | |||||||