InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KCNC3

Summary

InnateDB Gene

IDBG-64255.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNC3

Gene Name

potassium voltage-gated channel, Shaw-related subfamily, member 3

Synonyms

KSHIIID; KV3.3; SCA13

Species

Homo sapiens

Ensembl Gene

ENSG00000131398

Encoded Proteins

IDBP-64257

potassium voltage-gated channel, Shaw-related subfamily, member 3

IDBP-589256

potassium voltage-gated channel, Shaw-related subfamily, member 3

IDBP-586999

potassium voltage-gated channel, Shaw-related subfamily, member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. [provided by RefSeq, Jul 2008]
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Alternate splicing results in several transcript variants. [provided by RefSeq, Mar 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:50311937-50333515

Strand

Reverse strand

Band

q13.33

Transcripts

ENST00000376959	ENSP00000366158
ENST00000474951	ENSP00000432438
ENST00000477616	ENSP00000434241

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0008219	cell death
GO:0034765	regulation of ion transmembrane transport
GO:0046928	regulation of neurotransmitter secretion
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0030673	axolemma
GO:0031594	neuromuscular junction
GO:0032590	dendrite membrane
GO:0032809	neuronal cell body membrane
GO:0043679	axon terminus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000062785

View Gene Order

ENSBTAG00000039935

Not yet available

Pathways

NETPATH

REACTOME

REACT_75770

Voltage gated Potassium channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.467146

RefSeq

NM_004977 XM_006723203

HUGO

OMIM

CCDS

CCDS12793

HPRD

08886

IMGT

EMBL

GenPept

RNA Seq Atlas