Version 5.4
| Homo sapiens Gene: DEFB105B | |||
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| Summary | |||
| InnateDB Gene | IDBG-6426.5 | ||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||
| Gene Symbol | DEFB105B | ||
| Gene Name | defensin, beta 105B | ||
| Synonyms | |||
| Species | Homo sapiens | ||
| Ensembl Gene | ENSG00000186599 | ||
| Encoded Proteins |
defensin, beta 105B
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||
| Entrez Gene | |||
| Summary |
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105B, represents the more telomeric copy. [provided by RefSeq, Jul 2008] Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105A, represents the more centromeric copy. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||
| Type | Protein coding | ||
| Genomic Location | Chromosome 8:7487669-7489593 | ||
| Strand | Forward strand | ||
| Band | p23.1 | ||
| Transcripts |
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| Interactions | |||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||
| No orthologs found for this gene | |||
| Pathways | |||
| NETPATH | |||
| REACTOME |
Beta defensins pathway
Defensins pathway
Innate Immune System pathway
Immune System pathway
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| KEGG | |||
| INOH | |||
| PID NCI | |||
| Cross-References | |||
| SwissProt | Q8NG35 | ||
| TrEMBL | |||
| UniProt Splice Variant | |||
| Entrez Gene | 504180 | ||
| UniGene | Hs.381378 | ||
| RefSeq | NM_001040703 | ||
| HUGO | HGNC:29930 | ||
| OMIM | |||
| CCDS | CCDS34814 | ||
| HPRD | |||
| IMGT | |||
| EMBL | AB089180 AF540977 BC128437 BC128438 | ||
| GenPept | AAI28438 AAI28439 AAN33113 BAC10630 | ||
| RNA Seq Atlas | 245908 504180 | ||