InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ETS1

Summary

InnateDB Gene

IDBG-642787.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ETS1

Gene Name

protein C-ets-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002341

Encoded Proteins

IDBP-695286

protein C-ets-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20930145

[Homo sapiens] ETS1 transcription factor blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134954:
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:32358407-32430222

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000003022

ENSBTAP00000003022

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 83 interaction(s) predicted by orthology.

Predicted by orthology
Total	83 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0010595	positive regulation of endothelial cell migration
GO:0030154	cell differentiation
GO:0030578	PML body organization
GO:0042981	regulation of apoptotic process
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045765	regulation of angiogenesis
GO:0045786	negative regulation of cell cycle
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046677	response to antibiotic
GO:0048870	cell motility
GO:0051272	positive regulation of cellular component movement