InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MAPK8IP2

Summary

InnateDB Gene

IDBG-642814.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPK8IP2

Gene Name

C-Jun-amino-terminal kinase-interacting protein 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000030179

Encoded Proteins

IDBP-695312

mitogen-activated protein kinase 8 interacting protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000008735:
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:120127056-120137203

Strand

Forward strand

Band

Transcripts

ENSBTAT00000021360

ENSBTAP00000021360

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019894	kinesin binding
GO:0019901	protein kinase binding
GO:0030295	protein kinase activator activity

Biological Process

GO:0000165	MAPK cascade
GO:0001662	behavioral fear response
GO:0007254	JNK cascade
GO:0007617	mating behavior
GO:0010469	regulation of receptor activity
GO:0035176	social behavior
GO:0045860	positive regulation of protein kinase activity
GO:0046328	regulation of JNK cascade
GO:0046958	nonassociative learning
GO:0048813	dendrite morphogenesis
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Cellular Component

GO:0005737	cytoplasm
GO:0043025	neuronal cell body
GO:0097481	neuronal postsynaptic density

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000008735

View Gene Order

ENSMUSG00000022619

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

mmu04010

MAPK signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

G3X783

UniProt Splice Variant

Entrez Gene

618893

UniGene

Bt.35812

RefSeq

NM_001193199

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02015061

GenPept

RNA Seq Atlas

618893