Version 5.4
Bos taurus Gene: SPINLW1
Summary
InnateDB Gene IDBG-642939.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPINLW1
Gene Name eppin precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001495
Encoded Proteins
IDBP-695450
eppin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101448:
This locus represents naturally occurring read-through transcription between the neighboring SPINLW1 (serine peptidase inhibitor-like, with Kunitz and WAP domains 1) and WFDC6 (WAP four-disulfide core domain 6) genes. The read-through transcript encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Nov 2010] This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:75122286-75129707
Strand Reverse strand
Band
Transcripts
ENSBTAT00000001959 ENSBTAP00000001959
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005576 extracellular region
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000101448
View Gene Order
ENSMUSG00000017733
View Gene Order
Cross-References
SwissProt
TrEMBL Q32KP8
UniProt Splice Variant
Entrez Gene 768002
UniGene Bt.54195
RefSeq NM_001077062 XM_005214888
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109986 DAAA02036762
GenPept AAI09987
RNA Seq Atlas 768002

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca